Increased body weight may lead to which of the following conditions?

Increased body weight is associated with numerous physiological changes that can lead to a greater risk of developing insulin resistance. When the body accumulates excess fat, particularly in the abdominal region, it can result in an increase in the levels of free fatty acids and inflammatory markers in the bloodstream. This state, commonly referred to as metabolic dysfunction, can impair the way cells respond to insulin.

As insulin signaling becomes disrupted, the body may struggle to effectively take up glucose from the bloodstream, leading to elevated blood sugar levels. Over time, this can increase the likelihood of developing type 2 diabetes and metabolic syndrome, which are linked closely with obesity. Therefore, the association between increased body weight and the risk for insulin resistance is well-established in clinical studies and underscores the importance of maintaining a healthy weight for overall metabolic health.